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The average level of cAMP in GLP-1R KO mice was slightly lower than that in WT mice, but there was no significant difference between the two groups (Fig

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In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig