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With these preliminary data and new evidence, which consisted of a robust 36% deficit of cortical glutathione (GSH) the most abundant and primary antioxidant in living tissue in ME/CFS compared to controls, we competed for NIH funding and were awarded two grants, descriptively titled, Specificity and Validity of Oxidative Stress Model of Chronic Fatigue Syndrome (R01 MH100005) and [N-acetylcysteine] NAC for Treatment of Oxidative Stress in Chronic Fatigue Syndrome (R21 NR013650)

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