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Routhenstein says

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The gamma-glutamyl cycle does allow some tissues (particularly the liver, kidney, and lung epithelium) to utilize extracellular glutathione more directly via membrane transporters

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It does so by delivering nutrients directly into the bloodstream, where nutrients may be fully absorbed by your cells

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IDH1 is a cytosolic enzyme that metabolizes isocitrate to -KG to generate cytosolic NADPH

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