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The comparison with the crystal structure of GPX4 (PDB 6HN3) revealed that a modelated GpoA display orthologous residues that could conform the catalytic site of tis enzyme, including Gln 70 , Trp 124 and Asn 125 , but Cys 36 in the place of Sec 46 (Fig

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Estimated lifetime cardiovascular, kidney, and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal MRA compared with conventional care in patients with type 2 diabetes and albuminuria