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A National Institutes of Health study found that most people who consumed a diet high in ultra-processed foods averaged an additional 500 calories per day compared to those eating whole foods

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This functional unit strictly depends on the integrity of the gut epithelium, supported by junctional proteins, such as tight junctions (TJs), desmosomes, and adherent junctions, which form a physical barrier and connect adjacent epithelial cells, together with the lamina propria

Diet is long understood to be an important aspect of optimal HF care as emphasized in a 2019 consensus statement by the Heart Failure Society of America (HFSA)