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Semaglutide may reduce intrinsic factor production and gastric acid secretion, potentially impairing B12 absorptiona concern highlighted in postmarketing surveillance data and clinical observation

the 1 mg arm is the lowest measured human pharmacologic activity: Frias Lancet 2018

Semaglutide Research# Semaglutide has one of the most comprehensive clinical evidence bases of any peptide: SUSTAIN trials (7 Phase 3 studies in T2D), STEP trials (4+ Phase 3 studies in obesity), SELECT trial (cardiovascular outcomes), and FLOW trial (kidney outcomes)