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NICE guidelines for type 2 diabetes (NG28) and obesity do not include berberine in treatment algorithms

The GIP component adds: Enhanced Insulin Response: Even stronger blood sugar control than GLP-1 alone Better insulin secretion timing Improved insulin sensitivity in tissues Fat Metabolism Effects: GIP receptors exist in fat tissue May influence how body stores and uses fat Potentially increases fat burning Synergistic Appetite Suppression: GIP and GLP-1 together produce greater appetite reduction More potent satiety signals Stronger overall effect This explains why tirzepatide produces 5-7% more weight loss than semaglutidethe dual action is more powerful than GLP-1 alone

Lili Ladaga Editor GLP-1 RA Prescription Trends: January 2018 March 2025

Therefore, GLP-1RAs are of great significance in the treatment of NAFLD