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Retatrutide, like all GLP-1 receptor agonists, carries a warning about medullary thyroid carcinoma (MTC)

Interestingly, the HFD-induced impairments in microvascular perfusion were of similar magnitude to the impairments in the endothelium specific insulin receptor substrate-2 knock-out model which also has impaired insulin signalling in the endothelium and reduced eNOS activation [15]