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Alexandra Sinclair, a professor of neurology at the University of Birmingham, asked whether there are sex or age differences in the distribution of the GLP-1 receptors around the brain or in the access of the GLP-1 receptor agonists into the brain

The mechanism that helps GLP-1 medications work for weight loss becomes a problem when it goes too far

Conclusion: Our nonclinical studies demonstrate how a single, brief exposure to NTLA-2002 durably edits the KLKB1 gene in hepatocytes, resulting in deep, persistent reductions in prekallikrein, even through partial liver resection, suggesting a permanent effect

American Journal of Gastroenterology, 119(1 Suppl), S4397S4398