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Mechanism 1: Mitochondrial Oxidative Stress EGCG at high concentrations generates reactive oxygen species (ROS) inside hepatocytes, a mechanism documented in multiple cell-culture and rodent studies [7]

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Acta Sci Microbiol 1(8):3439 Lloyd-Price J, Arze C, Ananthakrishnan AN, Schirmer M, Avila-Pacheco J, Poon TW et al (2019) Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases