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Semaglutide agonizes one receptor (GLP-1)

Clinical Insight on GLP-1 for Chronic Weight Management in Adults: Patient Selection and Special Considerations

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Retatrutide is an investigational triple-agonist peptide designed to activate: GLP-1 (Glucagon-Like Peptide-1) receptors GIP (Glucose-Dependent Insulinotropic Polypeptide) receptors Glucagon receptors By targeting all three pathways, retatrutide addresses appetite regulation, insulin resistance, energy expenditure, and fat metabolism together rather than focusing on appetite suppression alone