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Brain organoids can closely mimic the complex cellular interactions and structures found in human brain tissue, making them particularly useful for understanding the pathophysiology of conditions like VaD that involve reduced blood flow and oxygen deprivation
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Mast cells (the cells which secrete histamine) also bridge communication between the immune and nervous systems by producing neurotransmitters and other mediators, such as NGF, serotonin, Substance P, and nitric oxide
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