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The weight of the accumulating evidence indicates that the age-related damage is an ineluctable consequence of normal oxygen metabolism associated with a relentless formation of reactive oxygen species (ROS

Consistent with this, expression levels of the long noncoding RNA, maternally expressed 3 ( MEG3 ) and glucose transporter 2 ( SLC2A2 ), both of which contribute to insulin synthesis and secretion (4346), increased in a step-wise fashion from the -1 to -4 subclusters (Figure 3D)