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35: 2326 Rebuzzi AG, Schiavoni G, Lanza GA, et al

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Thus, it seems like a no brainer if we employ methods which will increase the expression of genes that are involved in oxidative stress resistance, particularly oxidative damage, we may get the benefits of IGF-1 without the fall off in longevity

In the STZ-induced diabetic mouse model, DNA synthesis increases and peaks at day 2 in the proximal tubules, and the expression of various growth factors including epidermal growth factor (EGF), platelet-derived growth factor (PDGF), basic fibroblast growth factor (FGF), insulin-like growth factor-1 (IGF-1), hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) has been observed ( Figure 1 )