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The directionality of the effects, however, is inconsistent with earlier evidence of decreased GABA activity in schizophrenia. Thus, gender may influence the type of condition that results from the same neuroinflammatory process through the modulating effect of estrogen on genes

In this respect, selenosugars seem to be more feasible candidates, since they might exploit glucose- or other transporters (Campos-Bedolla et al., 2014) to cross the BBB and/or BCB whereas TMSe + is unlikely to be either effectively transported to the brain due to its positive charge and missing capability of effective metabolization in the brain tissue (Suzuki et al., 2006