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Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG

A key trial found that 600mg per day provided the best balance of effectiveness and tolerability, reducing instances of nausea, dizziness, and GI discomfort.4 A separate review of multiple studies supports this, concluding that 600mg daily is effective and well-tolerated for conditions like diabetic neuropathy, insulin resistance, and oxidative stress.5 That body of research has established 600mg of racemic ALA as a standard dose in clinical studies, thanks to its consistent balance of efficacy and tolerability

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But it also has the active derivative THD ascorbate, which maintains its effectiveness even in a creamy formulation