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Description

The major G allele at rs6043409, which confers risk for T1D, was found to be associated with higher cell-surface levels of isoform 1 SIRP on both CD4+ and CD8+ T cells, while the minor A allele reduced SIRP expression in a dose-dependent manner (83)

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doi: 10.1016/j.jhep.2023.08.026 11

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Add more non-ionic detergent, and pre-treat GST beads with a specific pH buffer, 0.1% Tween-20 (or other detergent)

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