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70 As cells use NADPH to reduce cystine to cysteine, the increased cysteine catabolism by CDO implies the increased consumption of NADPH, which will affect other cell metabolic pathways and the antioxidant capacity as well

It helps to reduce the production of melanin, which can lead to a brighter and more even skin tone

Considering the good response to the first multimodal treatment, we decided to schedule a second cycle of oral and topical treatment for 12 months, using the same agents and doses and reducing the frequency of peri-plaque penile injections with pentoxifylline 100 mg to one penile injection every 2 months for 12 months

Collection of blood and tissue samples At the end of the experimental period and following overnight fasting, rats were anesthetized using an intraperitoneal injection of ketamine (80 mg/kg body weight) and xylazine (10 mg/kg body weight)